A SYNTHETIC LETHAL SCREEN FOR SNAIL-INDUCED ENZALUTAMIDE RESISTANCE IDENTIFIES JAK/STAT SIGNALING AS A THERAPEUTIC VULNERABILITY IN PROSTATE CANCER

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer Electrical Parts remains a major cause of cancer-related death globally.The mainstay of treatment for advanced prostate cancer is targeting of androgen receptor signaling, including androgen depri

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Effect of wheelchair-modified rowing exercise on cardiometabolic risk factors in spinal cord injured wheelchair users: protocol for a randomised controlled trial

Introduction Cardiovascular and metabolic diseases are a growing concern for individuals with spinal cord injury (SCI).Physical inactivity contributes to cardiometabolic morbidity and mortality in the SCI population.However, previous studies have shown mixed results regarding the effects of exercise on cardiometabolic risk factors in individuals wi

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Total Harmonic Distortion of a Piezoelectric MEMS Loudspeaker in an IEC 60318-4 Coupler Estimation Using Static Measurements and a Nonlinear State Space Model

We propose a method to evaluate the Total Harmonic Distortion generated by a cantilever-based PZT loudspeaker inside an IEC 60318-4 coupler.The model is Carving Set validated using experimental data of a commercial loudspeaker.Using the time domain equations of the equivalent electrical circuit of the loudspeaker inside the coupler and a state spac

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The Rehabilitation-Related Effects on the Fear, Pain, and Disability of Patients With Lumbar Fusion Surgery: A Systematic Review and Meta-Analysis

Objective The lumbar fusion is an important surgery for the orthopedic diseases.The rehabilitation might improve the outcome of patients with lumbar fusion surgery.The rehabilitation-related effects can be revealed by a systemic Girls Halloween Top review and meta-analysis of randomized clinical trials (RCTs).The purpose of this study is to clarify

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